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In a recent study, a research team has used a peptide-based solution that is designed to be a new pain-free approach to minimize the effects of dental decay. This novel advance in dental therapeutics shows promise for reversing the enamel damage caused by dental decay.

The new treatment method involves using a peptide-based fluid which is applied to the surface of the tooth. Post application, the fluid starts and promotes tooth regeneration. Professor Jennifer Kirkham, the University of Leeds Dental Institute, a lead author in the study, explained “This may sound too good to be true, but we are essentially helping acid-damaged teeth to regenerate themselves. It is a totally natural non-surgical repair process and is entirely pain-free, too.”

The peptide-based fluid was created by a team from the School of Chemistry, University of Leeds, headed by Dr Amalia Aggeli. The fluid includes a peptide known as P 11-4 which, under certain conditions, changes into a fibrous like structure or gel.

The new fluid is said to work by filling the tiny holes on the tooth surface resulting from acidic attacks. Regeneration begins with the forming of a gel. This gel then forms a network that incorporates calcium leading to tooth mineralization and regeneration.

The effects of the new peptide fluid were recently assessed and the results were described as favorable. Professor Paul Brunton, from University of Leeds Dental Institute and one of the researchers, said “The results of our tests so far are extremely promising,”

He added “If these results can be repeated on a larger patient group, then I have no doubt whatsoever that in two to three years time this technique will be available for dentists to use in their daily practice. The main reason that people don't go to the dentist regularly is fear. If we can offer a treatment that is completely non-invasive, that doesn't involve a mechanical drill, then we can change that perceived link between dental treatment and pain.”

Professor Brunton concluded “This really is more than filling without drilling; this is a novel approach that enables the patients to keep their natural teeth!”